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Protective Actions of Ghrelin Global Cerebral Ischemia-Induced Memory Deficits (Basaranlar, G.)
Bibliographical information (record 264085)
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Protective Actions of Ghrelin Global Cerebral Ischemia-Induced Memory Deficits
Author:
 Basaranlar, G. Search Author in Amazon Books

Publisher:
Sprınger,
Edition:
 2014.
Classification:
 WL355
URL:
http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s11062-014-9454-1
Detailed notes
    - In our study, we investigated transient global cerebral ischemia (TGCI)-induced changes in spatial memory and motor activity together with apoptotic, oxidant, and NO/NOS signaling parameters in rats and the effects of treatment of animals with ghrelin. The TGCI-induced deficiencies of spatial memory and motor activity in the Y-maze and open field tests were attenuated by ghrelin treatment. Furthermore, ghrelin administration lowered the levels of caspase-3 and iNOS elevated by TGCI in the hippocampus. Thus, we conclude that ghrelin exerts a neuroprotective action against hippocampal TGCI injury via influencing apoptotic, oxidant, and/or NO/NOS pathways. If the underlying mechanisms of action of this agent are fully clarified, ghrelin might be a candidate drug for treatment of TGCI-induced memory impairments.
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Library
Section
EOL-433
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NEU Grand LibraryOnline (WL355 .P76 2014)
Online electronic
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