a Record control number 86260638

a ISSN 1300-1817

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WL355

b Item number .C36 2013

a Personal name Atabey, Cem.

h Medium Electronic Document

a Title Can Magnesium Sulphate Prevent Cerebral Ischemic Injury? An Experimental Study and Neuroradiological Evidence

c Statement of responsibility, etc Cem Atabey, Soner Şahin, Serdar Kahraman, Nail Bulakbaşı

c Date of publication, distribution, etc 2015.

a Summary, etc This study was designed to investigate whether magnesium sulphate prevents cerebral ischemic injury on an experimental rat model. Forty Sprague-Dawley rats were divided into 4 groups: I) the sham group; II) the group to which saline was applied prior to ischemia (control); III) the group that received MgSO4 (90 mg/ kg) intraperitoneally 30 minutes before ischemia; IV) the group that received MgSO4 (90 mg/ kg) intraperitoneally 30 minutes after ischemia. Infarct volumes were measured in all the rat groups by the use of MRI subsequently analyzed by the Workstation: Philips Easy Vision 5.2.1.1 Measurement analysis program. Total infarct volumes in the ischemic group that received saline without MgSO4, in the group that received MgSO4 after occlusion of the MCA and in the group that received MgSO4 before MCA occlusion were 231.7±34.03 mm³, 158.85±32.16 mm³ and 87.35±22.27 mm³ respectively. Total infarct volumes were significantly reduced in both the pre-occlusive and post-occlusive MgSO4 treatment groups (p<0.001). Our results support that magnesium displays a neuroprotective impact against cerebral ischemic injury. This therapeutic potential may have important clinical applicability if applied before neurovascular surgical interventions. However, the actual therapeutic potential of magnesium in humans and standardization of protocols need to be unveiled in further studies.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Cerebral ischemia

a Topical term or geographic name as entry element Nervous system

a Topical term or geographic name as entry element Brain surgery

a Topical term or geographic name as entry element cerebral arterial diseases

t Title Journal of Neurological Sciences

g Relationship information 2013, Vol. 30 Issue 1, p30-39. 10p.

x International Standard Serial Number 13001817